Role of Interleukin-4 in Regulation of Age-related Inflammatory Changes in the Hippocampus
Yvonne Nolan,
From the Physiology Department, Trinity College Institute of Neuroscience, the Biochemistry Department, Immune Regulation Research Group, Trinity College, Dublin 2, Ireland, Vasogen Ireland Limited, Shannon, Ireland
It is well documented that long term potentiation (LTP) is impaired in the hippocampus of the aged animal. Among the changes that contribute to this impairment is an increase in hippocampal concentration of the pro-inflammatory cytokine interleukin-1
(IL-1), and increased IL-1-induced signaling. In this study we investigated the possibility that these changes were a consequence of decreased concentration of the anti-inflammatory cytokine, IL-4, and decreased IL-4-stimulated signaling
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