As the lifespan of the population of developed countries increases, we are faced with managing a disease that is taking almost epidemic proportions and has a high social and economical cost; Alzheimer’s disease (AD). As everyone knows, AD robs the person not only of their memories but also their personalities and leaves only the shell of a once vibrant and functional human being that now requires care 24-h a day. Similar to the race to prevent, treat or cure cancer and heart diseases, it is essential and of extreme urgency to spearhead efforts against AD. To date, there are no effective treatments against AD. Amyloid is largely favored as the cause of the disease. Immense resources and efforts have been dedicated to anti-amyloid therapies and we are at the cusp of finding out if these will work of not. However, the arguments supporting the amyloid hypothesis can be challenged and an alternate model is presented herein.