Ideal Management of Diabetes Mellitus and Dementia
Hypoglycemic Episodes and Risk of Dementia in Older Patients With Type 2 Diabetes Mellitus
Rachel A. Whitmer, PhD; Andrew J. Karter, PhD; Kristine Yaffe, MD; Charles P. Quesenberry Jr, PhD; Joseph V. Selby, MD
Context: Although acute hypoglycemia may be associated with cognitive impairment in children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a risk factor for dementia in older patients with type 2 diabetes.
Objective: To determine if hypoglycemic episodes severe enough to require hospitalization are associated with an increased risk of dementia in a population of older patients with type 2 diabetes followed up for 27 years.
Design, Setting, and Patients: A longitudinal cohort study from 1980-2007 of 16 667 patients with a mean age of 65 years and type 2 diabetes who are members of an integrated health care delivery system in northern California.
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