Collagen VI protects neurons against A toxicity
Publisher:
Nature NeuroscienceDate published:
29 January, 2009Region:
International Publication type:
researchPublication link:
Collagen VI protects neurons against A toxicityFeatured item on home page:
no
Amyloid-
(A) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented A neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of A oligomers with neurons, enhanced A aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response and demonstrate its neuroprotective potential.
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