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Christmas 2009:Perceived age as clinically useful biomarker of ageing: cohort study

in
Publisher: 
BMJ
Author: 
Kaare Christensen, professor1, Mikael Thinggaard, mathematician1, Matt McGue, professor1,2, Helle Rexbye, research fellow1, Jacob v B Hjelmborg, associate professor1, Abraham Aviv, professor3, David Gunn, postdoctoral scientist4, Frans van der Ouderaa, vice president corporate research , director of business development4,6, James W Vaupel, professor5
Date published: 
15 December, 2009
Region: 
International

Publication type: 
research
Publication link: 
Perceived age as clinically useful biomarker of ageing: cohort study
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1 Danish Twin Registry and Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, DK-5000 Odense C, Denmark, 2 Department of Psychology, University of Minnesota, Minneapolis, MN, USA, 3 Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA, 4 Unilever Discover, Colworth House, Sharnbrook, Bedfordshire, 5 Max Planck Institute for Demographic Research, Rostock, Germany, 6 Netherlands Consortium for Healthy Ageing, Leiden University Medical Centre Leiden, LUMC, 2300RC Leiden, Netherlands

Correspondence to: K Christensen kchristensen@health.sdu.dk

Objective

To determine whether perceived age correlates with

survival and important age related phenotypes.

Design Follow-up study, with survival of twins determined up to January 2008, by which time 675 (37%) had died.

Setting Population based twin cohort in Denmark.

Participants 20 nurses, 10 young men, and 11 older women (assessors); 1826 twins aged ≥70.

Main outcome measures Assessors: perceived age of twins from photographs. Twins: physical and cognitive tests and molecular biomarker of ageing (leucocyte telomere length).

Results For all three groups of assessors, perceived age was significantly associated with survival, even after adjustment for chronological age, sex, and rearing environment. Perceived age was still significantly associated with survival after further adjustment for physical and cognitive functioning. The likelihood that the older looking twin of the pair died first increased with increasing discordance in perceived age within the twin pair—that is, the bigger the difference in perceived age within the pair, the more likely that the older looking twin died first. Twin analyses suggested that common genetic factors influence both perceived age and survival. Perceived age, controlled for chronological age and sex, also correlated significantly with physical and cognitive functioning as well as with leucocyte telomere length.

Conclusion Perceived age—which is widely used by clinicians as a general indication of a patient’s health—is a robust biomarker of ageing that predicts survival among those aged ≥70 and correlates with important functional and molecular ageing phenotypes.

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