Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland
Publisher:
Department of Geriatric Medicine, The Queen's University of BelfastDate published:
20 January, 2000Region:
Northern Ireland Publication type:
researchAlzheimer's disease (AD) is a progressive neurodegenerative disorder that has been associated, sometimes controversially, with polymorphisms in a number of genes. Recently the butyrylcholinesterase K variant (BCHE K) allele has been shown to act in synergy with the apolipoprotein E 
4 (APOE 4) allele to promote risk for AD. Most subsequent replicative studies have been unable to confirm these findings.
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